Medicine Physical Chemistry

Recommended Prerequisites

Not applicable.

Teaching Methods

The theoretical classes on the syllabus alternate with classes dedicated to the resolution of problems, and the coherence between the subjects presented in both reinforces the overall learning of the subjects. The lectures use audiovisual supports and specific bibliography. The classes dedicated to the resolution of problems also offer the opportunity to further explore the more difficult concepts. The exercises solved in such class follow the subjects of the lectures and stimulate the participation of the students in the resolution of the exercises.

Learning Outcomes

This course is designed to offer a quantitative perspective of Chemistry and to present physical models in which Chemistry is based to explain the molecular phenomena. It also aims at motivating the students to search for an understanding and predictions of the properties of molecules on the basis of laws and fundamental principles.
Specific objectives:
1. Acquire fundamental knowledge of Quantum Chemistry, Chemical Bonds, Spectroscopy, Thermodynamics and Kinetics.
2. Relate such knowledge tophenomena relevant to Medicina Chemistry
3. Relate spectrsocopy to the characterization of molecules and to diagnistic tools.
4. Relate Kinetics with Pharmacokinetics

Work Placement(s)

No

Syllabus

1. QUANTUM CHEMISTRY
Schrödinger's wave equation. The particle in a box. Schrödinger equation and the hydrogen atom. Atomic orbitals.
Multielectronic atoms. Molecular bonds.
2.SIMETRY
Simetry elements. Molecular simetry. Optical activity
3. SPECTROSCOPY
Rotational, vibrational and electronic spectrsocopy. Lasers. NMR
4. THERMODYNAMICS
Laws of thermodynamics. Free energy. Chemical equilibrium.
5. STATISTICAL THERMODYNAMICS
Macro and microstates. Boltzmann distribution. Partition functions. Thermodynamic quantities from partition functions.
6. KINETICS
Rate law. Reaction mechanism. Arrhenius equation. Experimental methods in the study of chemical reactions.
Parallel, consecutive and reversible reactions.. The rate determining step; steady-state approximation. The concept of transition state.
7. PHARMACOKINETICS
ADME of drugs. Routes of adminsitration. Compartimental models. Bioequivalence.

Head Lecturer(s)

Luís Alberto Esteves Batista de Carvalho

Assessment Methods

Evaluation
Exam: 100.0%

Bibliography

Physical Chemistry for the Chemical and Biological Sciences, Raymond Chang
Physical Chemistry. P. Atkins and Julçio de Paula
Cinetica Química. Sebastião Formosinho, Luis Arnaut