Pharmacology and Toxicology

Recommended Prerequisites

Human General Phisiology; Head and Neck Anatomy; Molecular and Cellular Biology; Biochemistry; Human General Anatomy.

Teaching Methods

There are expository, theoretical and collective teaching face-to-face classes. Small groups of students will be exposed to pharmacological demonstrations and problem-based learning strategies (practical and theoretical-practical training).

Learning Outcomes

This course unit type aims to dissect how substances used by man (drugs) reach and modulate their biological targets. Drugs that have favorable benefit/risk (therapeutic) and unfavorable benefit / risk (toxins) will be discussed. We aim to provide students with the ability to apply the principles of physiology to rationalize about drugs. We further aim to teach simple yet practical principles that lay the foundation of rational drug therapy. Rational and structured approach to choice of therapeutic drugs for specific clinical cases that do not require deep knowledge of pathophysiology will be conveyed in practical classes; we ultimately aim to empower future doctors to prescribe according to Evidence Based Medicine (eg Cook et al, Chest 1192 ; 102:2053 ) .

Work Placement(s)

No

Syllabus

-Introduction To Pharmacology and Toxicology. Bibliography.

- Pharmacokinetics: absorption, distribution, metabolism, excretion of drugs.

- Drug mechanism of action (Pharmacodynamics).

- Pharmacology of the autonomic nervous system (ANS).

- Pharmacology of inflammation and pain:

a) nonsteroidal and steroidal anti-inflammatory drugs.

b) "Peripheral-acting" and central–acting analgesics. Opioid agonists and antagonists.

e) Pharmacology of neuropathic pain.

f) Pharmacology of headache.

- Drugs that act in Central Nervous System.

- Skeletal muscle relaxants.

- Local and general anesthetics.

- Drugs used to tread blood diseases.

- Chemotherapeutic drugs.

- Endocrine drugs.

- Cardiovascular-renal drugs.

-Bronchodilators and other agents used in asthma.

-Drugs used in gastrointestinal diseases.

-Drug oral manifestations.

-Pharmacovigilance.

-Drugs in used in Emergency Room.

Head Lecturer(s)

Frederico Guilherme Sousa Costa Pereira

Assessment Methods

Continuous Assessment
Mini Tests: 100.0%

Final Assessment
Exam: 100.0%

Bibliography

-Terapêutica Medicamentosa e suas Bases Farmacológicas, 6ª edição. Coordenado por S. Guimarães, Daniel Moura e Patrício Soares da Silva. Porto Editora, 2014.
-Pharmacology and Therapeutics for Dentistry, 6ª edição. Por J.A. Yagiela, E.A. Neidle, F.J. Dowd. Publicado pela Mosby, 2011.
-Basic & Clinical Pharmacology, de Katzung, 13ª edição, editado pela McGraw-Hill, 2015.
-Goodman and Gilman’s. The Pharmacological Basis of Therapeutics, 12ª edição. Editado por A. G. Gilman et al. Pergamon Press, 2011.
-Guide to Good Prescribing, T.P.G.M.de Vries, R.H. Henning, H.V. Hogerzeil e D. Fresle. Editado pela Organização Mundial de Saúde, Geneva, 1995.