Clinical Pharmacokinetics

Recommended Prerequisites

It is recommended that the student has knowledge on health area, namely pharmacology and pharmacokinetics. Additionally, it is desirable to know English and Spanish, as foreign invetigators can give some lectures as well as some supporting material can be provided in these languages.

Teaching Methods

Theoretical classes will consist of oral exposition of the subjects, with integrated pedagogical methodologies (collaborative learning and flipped learning) that encourage the student's active participation in the learning process and motivate them.

Theoretical-practical classes will be based on the case-based learning (CBL) methodology, consisting on the discussion of clinical cases that apply theoretical concepts and simultaneously simulate the reality of clinical practice, with analysis, interpretation and discussion of results.

Learning Outcomes

• Identify the objectives and object of study of Clinical Pharmacokinetics;

• Knowing sources of inter- and intra-individual variability that condition the efficacy and safety of drugs;

• Name the reasons underlying the use of Clinical Pharmacokinetics in Dosage Individualization;

• Identify drugs and special populations that should be subject to pharmacokinetic monitoring;

• Apply pharmacokinetic parameters in dosage individualization/optimization;

• Apply different techniques and computer programs for monitoring and dosing individualization;

• Explain the procedure and need for pharmacokinetic monitoring of drugs at hospital level (antibiotics, antiepileptics, immunosuppressants, antidepressants, antipsychotics);

• Define new or optimized posology regimen.

Work Placement(s)

No

Syllabus

• General concepts of pharmacokinetics, pharmacodynamics, biopharmaceutical phase, excretion, disposition, elimination and therapeutic range;

• Characteristics of drugs and subpopulations subject to pharmacokinetic monitoring;

• Organization of a clinical pharmacokinetics service;

• Identify and predict the impact of inter- and intra-individual variability factors on the AMDE of drugs;

• Dosage individualization methods;

• Pharmacokinetic monitoring of antibiotics, antiepileptics, immunosuppressants, antidepressants, antipsychotics and their relationship with the disease;

• Interpret population pharmacokinetic models and apply them to new patients;

• Know the basic concepts of modeling.

Head Lecturer(s)

Ana Cristina Bairrada Fortuna

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

BAUER L. Applied Clinical Pharmacokinetics 3rd Ed. McGraw-Hill. 2014

BAUER L. Clinical Pharmacokinetics Handbook. McGraw-Hill. 2005

BURTON E, SHAW LM, SCHENTAG JJ, EVANS WE. Applied Pharmacokinetics & Pharmacodynamics. Principles of Therapeutics  Drug  Monitoring.  4ªEd, Philadelphia, Lippincott Williams & Wilkins 2006.

DIPIRO JT. Concepts in Clinical Pharmacokinetics. Fifth Ed. American Society for Health System Pharmacists. 2010.

EVANS, W. & SCHENTAG, W.J. (1992); Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring. 3th Ed. Vancouver: Applied Therapeutics.

WINTER M.E. Basic Clinical Pharmacokinetics. 5th Ed, Williams & Wilkins 2010.

R. Silva, …, A. Fortuna, doi: 10.3390/pharmaceutics12100943

R. Silva, …, A. Fortuna, DOI: 10.3390/biomedicines10092127

R. Silva, …, A. Fortuna, DOI: 10.3390/pharmaceutics15061704

M. Aquino, …, A. Fortuna, DOI: 10.3390/antibiotics12020373

Bibliografia complementar fornecida pela Professora