Clinical Pharmacokinetics

Year
1

Academic year
2022-2023

Code
02556589

Subject Area
Health Sciences and Technologies

Language of Instruction
Portuguese

Mode of Delivery
Face-to-face

Duration
SEMESTRIAL

ECTS Credits
5.0

Type
Compulsory

Level
2nd Cycle Studies - Mestrado

Recommended Prerequisites

The recommended rules required for the Master registration.

Teaching Methods

For the student acquires the skills proposed for this curricular unit, lessons will be based on oral presentations of the matter following its framework in the curricular unit. Practical exercises that apply theoretical concepts, with analysis, interpretation and discussion of results will be conducted in practical classes

Learning Outcomes

Development of skills to interpret the evolution of serum concentrations versus time integrating multidisciplinary information (physiology, pathology, pharmacology, pharmacokinetics and pharmacotherapy).

Application of mathematical models that characterize the time course of drug concentrations in biological fluids in order to understand the influence of pathophysiological variables on drug pharmacokinetic profile and its application in drug therapeutic drug monitoring and optimization of drug dosage regimen.

Work Placement(s)

Syllabus

1. Introduction to Clinical Pharmacokinetics;
2.Clinical Pharmacokinetics in special situations: Pediatrics, Geriatrics, Pregnancy, Obesity, Organ failure, Poisoning;
3. Correlation between serum concentration and pharmacological response;
4. Characterize and distinguish non-compartmental and compartmental pharmacokinetics models;
5. Monitoring methodology;
6. Pharmacokinetics and monitoring of (I) Aminoglycosides (II) vancomycin, (III) Antiepileptic, (IV) Digoxin.

Head Lecturer(s)

Maria Margarida Coutinho de Seabra Castel-Branco Caetano

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

Evans W, Schentag J, Jusko W. Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring. Third edition. Vancouver: Applied Therapeutics. 1992.

Winter M. Basic Clinical Pharmacokinetics. Third edition. Washington: Applied Therapeutics, 1994.

Rowland M, Tozer T. Clinical Pharmacokinetics. Third edition. Philadelphia: Williams& Wilkins, 1995.

Winter M.E. Basic Clinical Pharmacokinetics. 5th Ed, Williams & Wilkins, 2010.

Bibliografia complementar fornecida pelos Professores da unidade curricular (Capítulo de Livros, Guidelines Internacionais e Artigos científicos).