Pharmaceutical Physics

Recommended Prerequisites

Knowledge in Physical Chemistry, Instrumental Methods of Analysis, Analytical Chemistry and Pharmaceutical Technology.

Teaching Methods

In order to achieve the objectives set for the course, the teaching methodology used is:
Lectures
Expository method supported by electronic means (basically slides and videos)
Induction for student participation in scientific like.

Learning Outcomes

1. Knowledge and understanding capacity
1.1. recognize and apply concepts and principles on particle technology, powder compression and disperse systems;
2. Application of knowledge and understanding
2.1. to apply the knowledge acquired in the field of pharmaceutical systems;
3. Realization of judgment / decision making
3.1. Ability to interpret problems within the general framework on physical pharmacy;
4.  Communication
4.1. Have acquired powers to transmit information and knowledge in the field of Pharmaceutical Physics.

Work Placement(s)

No

Syllabus

A. Particle Technology
I Introduction
II Implementation stages
III Measurement Technology
IV Particle size analysis and characterization
V Classification Process

VI Nucleation and crystallization
VII Properties of Solids (polymorphism)
B- Compression Physics
I Introduction
II Measuring devices
III Technical interpretation
a) Heckel equation
b) Compaction
c) Curves force-displacement and force-time
IV Hardness measurements
V Compression excipients
C-Dispersed systems
I-Colloidal systems
II Colloid stability
III Interaction forces between colloidal particles
IV Repulsion between hydrated surfaces
V- Rheology of emulsions
VI Rheology of suspensions
VII cell-cell and cell-surface
VIII Foams.

Head Lecturer(s)

João Carlos Canotilho Lage

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

-M.E. Aulton, Pharmaceutics. The Science of Dosage form design, ed. Churchill Livingstone, London 2000.
-John Knowlton and Steven Pearce, Handbook of Cosmetic Science and Technology. Section 1- Raw Materials, ed. Elsevier Advanced Technology, Amsterdam, 1993.
- Frank Etzler, Rheological Characterization of Hydroxypropycellulose Gels, Drug Development and Industrial Pharmacy, Vol. 25, nº 2, 1999.
-Vila Jato, Tecnologia Farmacêutica, Formas Farmacêuticas, Vol. II, ed Síntesis, Madrid, 1997.
-Rolf Hilfiker, Polymorphism in the Pharmaceutical Industry, ed. Wiley-VCH, Weinheim, 2006.
-Alexander T. Florence, Juergen Siepmann, Modern Pharmaceutics, Vol 1 and Vol.2, Fifth Edition, CRC Press, Boca Raton, FL, 2009.