Technologies of Controlled-Release Systems

Recommended Prerequisites

Pharmacokinetics, Pharmaceutical Technology, Mathematics.

Teaching Methods

Master classes with description and illustration of the concepts using slides. Use of multimedia and laboratory part of filming done in FFUC. Discussion resolution and formulation problems.

Learning Outcomes

- Know and explain the importance of controlled release of drugs:
- Ability to explain the relationship between pharmacokinetics of the drug and design of modified drug delivery systems.
- To know and exemplify the main technologies of preparation of modified-release systems.
- To know and justify the specificity control of modified release systems.

Work Placement(s)

No

Syllabus

Controlled release of drugs; facts and myths; Pharmaceutical Technology of modified drug release systems;
modified release systems for oral delivery, physiologic and physical chemistry impact on pharmaceutical development; Dosage forms and administration routes; Colon delivery, physiologic and polymers influence.

Head Lecturer(s)

António José Ribeiro

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

-Hsieh, D.S.T. Subcutaneous controlled delivery of estradiol by compudose implants: in vitro and in vivo evaluations. Drug Develop. & Ind. Pharm. 1987, 13, 2651–2666.
-Karim, A. Transdermal absorption: a unique opportunity for constant delivery of nitroglycerin. Drug Develop. & Ind. Pharm. 1983, 9, 671.
-Cardinal JR. Matrix systems. In Langer RS, Wise DL, editors. Medical Applications of Controlled Release: Classes of Systems, Vol. 1, CRC Press, Boca Raton, FL, 1984, pp. 41–67.
-Siepmann J, Siepmann F. Mathematical modelling of drug delivery. Int. J. Pharm. 2008;364:328–343.