New Processes in the Chemo-Pharmaceutical Industry

Year
1
Academic year
2023-2024
Code
02556337
Subject Area
Health Sciences and Technologies
Language of Instruction
Portuguese
Mode of Delivery
Face-to-face
Duration
SEMESTRIAL
ECTS Credits
6.0
Type
Compulsory
Level
2nd Cycle Studies - Mestrado

Recommended Prerequisites

Organic Chemistry, Synthesis and Catalytic Processes.

Teaching Methods

Theoretical classes, with discussion, giving relevant examples. In the theoretical-practical classes, demonstrative exercises will be presented and discussed.

Learning Outcomes

Provide students with the knowledge and tools needed in order to be integrated in the chemical-pharmaceutical industry, either in the optimization of chemical process or in the implementation of new technologies necessary for their development and competitiveness.

Work Placement(s)

No

Syllabus

Organocatalysis and Organocatalysts Advantages of organocatalysis Asymmetric Organocatalysed reactions General mechanisms of organocatalysis Examples of reactions catalyzed by Organocatalysts Aldol Condensation reactions
Michael Reactions
Cyanation and Strecker reaction.
Sustainable development and Green Chemistry.
Atom economy.
Atom economics reactions.
Catalysis and Green Chemistry.
Basic concepts in heterogeneous catalysis.
Heterogeneous catalysis in chemical and pharmaceutical industries.
Basic concepts in homogeneous catalysis.
Environmentally friendly Lewis acids.
Phase transfer catalysts.
Organic solvents.
Environmentally friendly organic solvents.
Solvent free systems.
Supercritical fluids. Supercritical Carbon dioxide. Supercritical water.
Ionic liquids in pharmaceutical chemistry.
Ionic liquids as catalysts.
Ionic liquids as solvents.
Fluorous Biphasic solvents.

Emergent technologies with interest in pharmaceutical chemistry.

Head Lecturer(s)

Maria Elisa da Silva Serra

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

Albrecht Berkessel, Harald Groger, Asymmetric Organocatalysis –From Biomimetic Concepts to Applications in Asymmetric Synthesis, Wiley-VCH, New York, 2005.
Green Chemistry:An Introductory Text, Ed by Myke Lancaster, RSC, 2002; Ionic Liquids in Synthesis, Ed by P. Wasserscheid and T. Welton, Wiley-VCH, 2004; J.L. Tucker, Org. Proc. Res. Dev., 2006, 10, 315.
Chemistry in Alternative Reaction Media, D.J. Adams, P.J. Dyson., S.T. Tavener, Wiley, 2006.
Anastas PT, Levy IJ, Parent KE (Eds). Green Chemistry Education. Changing the Course of Chemistry, ACS Publications, Washington DC, 2009.
Ballini R (Ed). Eco-Friendly Synthesis of Fine Chemicals. RSC Green Chemistry Series, Royal Society of Chemistry publications Cambridge, 2009.