Organic Chemistry I

Recommended Prerequisites

Skills on subjects of the course unit Physics and Chemistry of the proofs of admission in the Master in Pharmaceutical Sciences Course.

Knowledge of English Language.

Teaching Methods

The theoretical classes will be taught by the projection of slides, which are then placed on the platform “inforestudante”.

The practical-laboratorial classes will be taught through oral presentations by groups of students, as well as by the practical execution of these works.

Learning Outcomes

THEORETICAL

Classifying the organic compounds and name them with trivial and IUPAC System

Interpret their reactivity

Classifying the organic reactions: Electrophilic addition, electrophilic substitution; elimination; transposition, nucleophilic addition, nucleophilic substitution, radical addition; radical substitution and polymerization

To describe and explain the chemical mechanisms

To characterize the structural aspects that affect the reactivity

To indicate the general physical properties of the organic compounds

To predict and classify the chemical behavior of the studied compounds

Planning chemical syntheses, using suitable protecting groups for various functional groups and judiciously choosing selective reaction conditions

PRATICAL-LABORATORIAL

Capability to research, organize and transmit the fundamentals and execute, according to safety rules, laboratorial procedures suitable to the execution of separation, characterization, synthesis and processing of organic compounds.

Work Placement(s)

No

Syllabus

THEORETICAL TEACHING

Introduction to Organic Chemistry

Atomic and molecular structure

Radical substitution reactions

Alkanes and Cycloalkanes: Structure; properties; naming; preparation and reactions

Stereochemistry and stereoisomerism

Nucleophilic substitution and elimination reactions

Structure; properties; naming; preparation and reactions of:

-Alkanes and Cycloalkanes

-Haloalkanes

-Alcohols

-Ethers and Epoxides

Introduction to the study of the spectroscopic methods (IR,  NMR and MS)

PRACTICAL-LABORATORIAL

Basic rules of safety for organic chemistry laboratories

Glass material and other equipment used in the chemistry laboratory

Execution of laboratorial experiments:

Thin layer chromatography (TLC) and revelation techniques of mixtures of organic compounds/standards (analgesic tablets)

Distillation and boiling points

Simple

With vacuum

Fractionated

Refractive index

Crystallization

Liquid-liquid multiple extraction

Melting points.

Head Lecturer(s)

Anthony Joseph Burke

Assessment Methods

Assessment
Laboratory work or Field work: 30.0%
Exam: 70.0%

Bibliography

Teórico|Theoretical

Volhardt K P C; Schore N E, Organic Chemistry W H Freeman & Company: New York, 7th Ed, 2014

Brown W W, Organic Chemistry, Saunders College Publishing,: London 3th Ed 2002

Fox M A; Whitesell J K, Organic Chemistry, Jones & Bartlett Publishers: Sudbury, 3th Ed, 2003

Solomons T W G, Frythle G B Organic Chemistry, New York: John Wiley&Sons, 8th Ed 2003

 

Laboratorial

Hammond C N, Mohrig J R, Morrill T C, Neckers D C, Experimental Organic Chemistry, New York, W. H. Freeman & Company, 1999

Ault A, Techniques and Experiments for Organic Chemistry, University Science, Books: USA, 6thEd, 1998

Castanho M A R B, Castro C A N C, Lampreia I M S, Norberto M, Panplona M T, Meireles M M, Mira L, Santos F J V, Simões J A M, Guia do Laboratório de Química e Bioquímica, Lisboa, Lidel, 2000

Pombeiro A J L O, Técnicas e Operações Unitárias em Química Laboratorial, Fundação Calouste Gulbenkian, 1983.

Mayo D W, Pike R M, Trumper P K, Microscale Organic Laboratory, Wiley Ed, 3rd ed, 1994.