Organic Chemistry I

Recommended Prerequisites

Skills on subjects of the course unit Physics and Chemistry of the proofs of admission in the Master in Pharmaceutical Sciences Course. Knowledge of English Language.

Teaching Methods

The theoretical classes will be taught by the projection of slides, which are then placed on the platform “inforestudante”

The theoretical-practical classes will be taught by projection of slides and with the active participation of students in problem solving, individually or in groups.

The practical-laboratorial classes will be taught through oral presentations by groups of students, as well as by the practical execution of these work.

Learning Outcomes

- Classifying the organic compounds and name them with trivial and IUPAC System

- Interpret the reactivity of the organic molecules

- Classifying the organic reactions: Electrophilic addition, electrophilic substitution; elimination; transposition, nucleophilic addition, nucleophilic substitution, radical addition; radical substitution and polymerization

- To describe and explain the mechanisms of reactions

- To characterize the structural aspects that affect the reactivity

- To indicate the general physical properties of the organic compounds

- To predict and classify the chemical behavior of the compounds which belong to the more representative groups

- Planning chemical syntheses; using suitable protecting groups for various functional groups and choosing selective reaction conditions

- To know the basics of different spectroscopic methods, to interpret their spectra and properly utilize the information obtained in the identification and structural elucidation of organic compounds

Work Placement(s)

No

Syllabus

Theoretical

Introduction to Organic Chemistry

Atomic and molecular structure

Radical substitution reactions

Alkanes and Cycloalkanes: Structure; properties; naming; preparation and reactions

Stereochemistry and stereoisomerism

Nucleophilic substitution and elimination reactions

Structure; properties; naming; preparation and reactions of:

- Alkanes and Cycloalkanes

- Haloalkanes

- Alcohols

- Ethers and Epoxides

- Introduction to the study of the spectroscopic methods (IR,  NMR and MS)

 

Theoretical-practical

Solving exercises

 

Practical-laboratorial

Safety in organic chemistry laboratories

Glass material and other equipment

Execution of the following laboratorial experiments:

Thin Layer Chromatography (TLC)

Simple distillation and boiling points

Fractionated distillation and boiling points

Vacuum distillation

Crystallization

Liquid-liquid multiple extraction

Melting points

Refractive index.

Head Lecturer(s)

Fernanda Maria Fernandes Roleira

Assessment Methods

Assessment
Laboratory work or Field work: 5.0%
Synthesis work: 7.5%
Laboratory notebook : 7.5%
Mini Tests: 10.0%
Exam: 70.0%

Bibliography

Ensino teórico/theoretical teaching
Volhardt K P C; Schore N E,Organic ChemistryW H Freeman & Company: New York, 7thEd, 2014
Brown W W,Organic Chemistry,Saunders College Publishing,: London 3thEd 2002
Solomons T W G, Frythle G BOrganic Chemistry, New York: John Wiley & Sons,8thEd 2003
Ensino prático-laboratorial/practical-laboratory teaching
Hammond C N, Mohrig J R, Morrill T C, Neckers D C,Experimental Organic Chemistry, New York, W. H. Freeman &
Company, 1999
Ault A,Techniques and Experiments for Organic Chemistry, University Science, Books: USA, 6thEd, 1998
Castanho M A R B, Castro C A N C, Lampreia I M S, Norberto M, Panplona M T, Meireles M M, Mira L, Santos F J V,
Simões J A M,Guia do Laboratório de Química e Bioquímica, Lisboa, Lidel, 2000
Brewster R Q, Mcewen W E, Vanderwert C A,Curso Practico de Quimica Organica, Editorial Alhambra, 2ª ed,1970
Mayo D W, Pike R M, Trumper P K,Microscale Organic Laboratory, Wiley Ed, 3rded, 1994