Pharmacology I

Recommended Prerequisites

Cell Biology, Molecular Biology, Biochemistry, Histology, Physiology and Human Anatomy, Pathophysiology.

Teaching Methods

The teaching methodologies in this course include:

 - lectures

 - practical-laboratory  classes

 To develop strategies and dynamic procedures, in particular through flipped classrooms, in order to gain the students active participation, challenging them constantly to seek solutions to the problems. In this type of education, the teaching practice has defined goals that express different levels of competence, ie, the development of personal, interpersonal and instrumental competencies, as well as professional skill and dexterity.

Learning Outcomes

The teaching of Pharmacology involves the study of the origin, properties, biochemical and physiological effects, mechanisms of action, absorption, distribution, biotransformation and excretion, as well as their uses, with therapeutic purposes, or not, of the various drugs. The student must be able to understand and discuss the mechanisms of action and the pharmacodynamic and pharmacokinetic profile of the most representative drugs of the different pharmacotherapeutic groups. The pharmacist's intervention in support of the instituted therapy should be based on a solid knowledge of pharmacology, so that he can comment on the desirable and undesirable actions of the drugs in the body, thus guaranteeing an important support to society in the establishment and fulfillment of effective therapy.

Work Placement(s)

No

Syllabus

TEORIC COMPONENT 

Antipsychotics

Antidepressants, anxiolytics, sedatives and hypnotics

Antiepileptic drugs

Drugs used in neurodegenerative diseases

Central nervous system stimulants

Drugs that act on the autonomic nervous system

Pain pharmacology: centrally acting analgesics and centrally acting muscle relaxants, cannabinoids and drugs used to treat headaches

General and local anaesthetics

Cancer pharmacology: chemotherapy, monoclonal antibodies (mAbs), small immunomodulatory molecules, adoptive cell therapy, oncolytic viruses and dendritic cell vaccines

PL

In vivo models for assessing anxiolytic, antidepressant, cognitive, motor, and analgesic activities.

In vitro models for screening drugs with neuroprotective activity, for calculation of the IC50 of drugs used in the treatment of glioblastomas, for assessment of drug permeability through the BBB, and for the characterization of the response of the SNA to noradrenaline.

Head Lecturer(s)

Maria Teresa da Teixeira Cruz Rosete

Assessment Methods

Assessment
Laboratory work or Field work: 25.0%
Exam: 75.0%

Bibliography

Terapêutica medicamentosa e suas bases farmacológicas. Manual de Farmacologia e Farmacoterapia de Serafim Guimarães, Daniel Moura e Patrício Soares da Silva. Porto Editora. 6ª Edição. 2014 ISBN: 978-972-0-01794-9

Rang and Dale´s Pharmacology. Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G. 9th Edition Churchill Livingstone. 2019. ISBN: 978-0-7020-3471-8

The Pharmacological Basis of Therapeutics. Bruton L, Chabner B, Knoliman B; Goodman & Gilman´s. 13th Edition. McGraw-Hill. 2018. ISBN: 978-0-07-175252-4

Molecular Neuropharmacology: A Foundation for Clinical Neuroscience. Eric Nestler & Steven Hyman & Robert Malenka. 3rd Edition. McGrawHill. 2015. ISBN 13: 9780071827690

Basic and Clinical Pharmacology. Kartzung, BG. Lange 14th Edition; 2018

Artigos Científicos/ Scientific papers