Pharmaceutical Chemistry II

Recommended Prerequisites

Organic Chemistry; Biochemistry; Biology; General Pharmacology; Pharmaceutical Chemistry I.

Teaching Methods

Theoretical teaching: Expositive lectures, including examples and case studies.

Practical teaching: Experimental work in laboratory and seminars.

Learning Outcomes

- To contribute to the knowledge of the molecular basis of diseases and of their control.

-To conduct a full analysis of SAR to predict potency and selectivity towards the receptor, the duration of action and the potential for adverse reactions.

- To understand the relevance of the chemistry of the drugs in their action and therapeutic use. Moreover, with this knowledge to have the ability to make options on the therapeutics.

- To acquire the main concepts in the area of Pharmaceutical Chemistry, under the scope of a Pharmacy

curriculum.

- To gain the ability to have a critical and scientific thinking of decisions on drug use.

- To transmit a professional responsibility on therapeutic decisions.

- To call the attention on the unique role of the pharmacist, as a professional integrated in a health team,

to use Chemistry for rational decisions on drugs use.

Work Placement(s)

No

Syllabus

SYSTEMATIC STUDY OF DRUGS
1.    Drugs Acting on the Hormonal Systems
1.1.    lnsulin and drugs to treat diabetes
1.2.    Adrenocorticoids
2.    Drugs Acting  on the lmmune System
2.1.    Non-steroidal anti-inflamatory drugs
2.2.    Anti-histamines and related antiallergic and antiulcer drugs
3.    Women's Health
3.1.    Steroidal estrogens
3.2.    Progestins
3.3.    Progesterone receptor antagonists
3.4.    lnfertility drugs
3.5.    Selective estrogen receptor modulators
3.6.    Aromatase inhibitors
4.    Men 's Health
4.1.    Androgens
4.2.    Anabolic agents
4.3.    Drugs for prostatic diseases
4.4.    Drugs for erectile function
4.5.    Therapies for prostate cancer

Practical Classes

Pharmaceutical analisys in APIs and in dosage forms:
-    Diazepam
-    Prednisolo
-     Sodium salicylate
-    Etambutol chloride
-    Dapsone
-    Naproxeno (FP)
-    Amoxicilina (USP).

Head Lecturer(s)

Jorge António Ribeiro Salvador

Assessment Methods

Assessment
Laboratory work or Field work: 20.0%
Exam: 80.0%

Bibliography

Aulas teóricas:
-Williams, D A and Lemke, T L, Foye’s Principles of Medicinal Chemistry, Lippincott Williams & Wilkins, 7th Ed.,
2013
-Silverman, R.B., The Organic Chemistry of Drug Design and Drug Action, Academic Press, 2nd Ed., 2008
-Thomas Gareth, Medicinal Chemistry , Wiley, 2"d Ed., 2007
Aulas laboratoriais:
- US Pharmacopeia, National Formulary
- Farmacopeia Portuguesa
- Pharmacopee Europeene
- Ault, A. Techniques and Experiments for Organic Chemistry, 6th Ed.; University Science Books; USA ; 1998
- Pavia, D. L., Lampman, G. M. and Kriz, G. S. lntroduction to Spectroscopy, 4th Ed., 2009.