Pharmaceutical Technology I

Recommended Prerequisites

Biopharmacy, Analytical Chemistry, Organic Chemistry.

Teaching Methods

Students are assessed upon final exam, which includes a theoretical and a practical part  (which deals with the knowledge discussed in laboratory classes), corresponding, respectively, to 75 and 25% of the final grade. The student is considered approved uponreaching a rate equal to or greater than ten (out of 20).

Learning Outcomes

The theoretical and laboratory course on Pharmaceutical Technology I is organized so that the student:
- Realizes what is the process of Pharmaceutical Development and how does Pharmaceutical Technology I fit in;
- Understand the importance of preformulation;
- Distinguish the role of each class of excipients used in the formulation of solid dosage forms and the corresponding mechanism of action.
- Masters the aspects associated with the production of solid dosage forms, including the specific problems inherent to each one of the dosage forms addressed in the course. In this respect, the student must develop the ability to know which preparation method best suits a particular formulation.
- Understand the basic aspects of solid dosage forms quality control.

The implementation of the objectives described will enable students to develop the following skills: problem solving; critical thinking; autonomous learning; oral and written communication; concern for quality.

Work Placement(s)

No

Syllabus

Theoretical component
Contextualization. Pre-formulation. Biopharmaceutical classification system. Powders: Unit operations, Development of pharmaceutical formulations with low percentage of API, segregation and transfer of powders, Sampling, Material Sampling, Particle size analysis. Forms obtained by dividing post: medicated powders: advantages, formulation. Tablets: Formulation, compression, methods of preparation, coating of tablets, types of tablets, Quality Control. Capsules: Formulation, Production and Quality Control. Lyophilization. Packaging. Production Units of solid dosage forms.

Laboratory component
Preparation and control of sachets.
Preparation and control capsules.
Compression: wet granulation and direct compression.
And control preparation of tablets by wet granulation.
And control preparation of tablets by direct compression.
Quality control of tablets.
Dissolution assay.
Lyophilization.

Head Lecturer(s)

João Nuno Sereno Almeida Moreira

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

Aulton's Pharmaceutics: The Design and Manufacture of Medicines, 4th edition, Churcill Livingstone, M. E. Aulton (Ed.), Kevin M. G. Taylor, 2013.

 

Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form, Informa Healthcare Press, Mark Gibson (Ed.), 2009.

 

Pharmaceutical Dosage Forms: Tablets, Vol. 1 (Hardcover), 2nd edition, Herbert Lieberman (Editor), Leon Lachman (Editor), Joseph B. Schwartz (Editor), 1989