Pharmaceutical Technology III

Recommended Prerequisites

Applied Physics, Physical Chemistry, Organic Chemistry, Biology.

Teaching Methods

The lectures have lasting sixty minutes and follow the model of masterful lesson. The presentation of the syllabus of each class is always preceded by a brief introduction, making up the connection with the previous lesson, if there is continuity. At the end of each lesson are highlighted the most relevant concepts and provided material support teaching, together with the detailed summary of matter taught, accompanied by the respective bibliography. The laboratory sessions lasting two hours to enable practical work described above.

Learning Outcomes

The main purpose of this course is to impart knowledge to students about technologies and dosage forms that were not covered in the courses of Pharmaceutical Technology I and II, which are considered essential for graduate training.
• To plan and conduct drug stability studies;
• To know and prepare new therapeutic systems for drug administration: pellets, microparticles, cyclodextrins, bioadhesive polymers, lipid nanoparticles and polymeric micelles;
• To justify the importance of pre-formulation studies in drug development;
• To know and prepare modified drug release systems;
• To plan and conduct drug dissolution studies and present a critical analysis of the obtained results;
• To plan and conduct validation studies of pharmaceutical processes.

Work Placement(s)

No

Syllabus

Plenary lectures:

1. Introduction
2. Stability studies of pharmaceutical formulations
3. Chemical kinetics of drug degradation
4. Pellets
5. Dissolution studies of solid oral formulations
6. Microencapsulation
7. Lipid nanoparticles
8. Modified drug delivery systems
9. Mucoadhesion
10. Pharmaceutical aerosols
11. Pharmaceutical applications of cyclodextrins
12. Polymeric micelles

Laboratory program:

1. Stability studies
2. Preparation of hydrophilic tablets
3. Pre-formulation studies
4. Dissolution studies of solid oral formulations
5. Validation studies
6. Preparation and quality control studies of pellets
7. Pellet coating
8. Microencapsulation
9. Resolution of practical problems about chemical kinetic.

Head Lecturer(s)

António José Ribeiro

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

ICH Topic Q 1 A Stability Testing of new Drug Substances and Products. EMEA, November, 2005;

 

Siewert et al, FIP/AAPS Guidelines to Dissolution/in Vitro Release Testing of Novel/Special Dosage Forms. AAPS PharmSciTech, (2003), 4, (81), 1 – 10;

 

Smart, J. D. “The basics and underlying mechanisms of mucoadhesion”. Advanced  Drug Delivery Reviews, (2005), 1556 – 1568;

 

Francisco Veiga, Ana Rita Figueiras, Amélia Vieira. Oral Drug Delivery with Cyclodextrins. Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine. Current and Future Industrial Applications. Ed. Wiley. (2011), Chapter 10, pags. 177 – 196;

 

Qui, Y. Rational Design of Oral Modified - release Drug Delivery Systems. Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Elsevier Inc, (2009);

 

Aulton, M. “Libertação pulmonar de fármacos” Delineamento de formas farmacêuticas. Ed. Artmed, (2009) pag. 478-493.