Organic and Biomolecular Chemistry

Recommended Prerequisites

Knowledge of English.

Teaching Methods

Lectures – projection of slides and placed on the Nónio
Practical laboratory classes – oral presentations, pratical execution of the works and elaboration of laboratory notebooks.

Learning Outcomes

This course has the following objectives:
Classification and nomenclature of organic compounds;
Interpret the reactivity of organic molecules;
Classify organic reactions;
Describe and explain the mechanisms of some organic reactions;
Characterize the structural aspects that influence reactivity;
Indicate the general physical properties of various types of compounds;
Knowi the structure and some reactivity of the different biomolecules;
Understand the most common mechanisms in biological chemistry;
Perform basic laboratory techniques and initiate the synthesis of organic compounds, through encouraging observation, interpretation and the discussion of results obtained.

Work Placement(s)

No

Syllabus

Lectures:
Atomic and molecular structure.
Stereochemistry, Stereoisomerism and Chirality.
Nomenclature, structure, properties, preparation methods and reactivity: alkanes and cycloalkanes, alkanes, aromatic hydrocarbons, alkyl halides, alcohols, ethers, aldehydes and ketones, carboxylic acids and derivatives (chlorides and acid anhydrides, esters and amides), Amines, Aromatic Heterocycles.
Biomolecules: Lipids, Carbohydrates, Amino Acids, Peptides, Proteins and Nucleic Acids.
Mechanisms in biological chemistry:Functional groups, acids and bases, electrophiles and nucleophiles; mechanisms of electrophilic and nucleophilic addition, nucleophilic substitution, elimination, oxidations and reductions.
Practical laboratory classes:
Safety, materials and equipment;
Crystallization; thin layer chromatography; melting points, simple distillation, fractional distillation and separation of two organic compounds by extraction and drying processes.
Synthesis of a Diels-Alder adduct.

Head Lecturer(s)

Fernanda Maria Fernandes Roleira

Assessment Methods

Assessment
Evaluation Final classification: Practical laboratory evaluation: 30.0%
Continuous evaluation or written laboratory exam Theoretical evaluation: 70.0%

Bibliography

Lectures:
Volhardt, K. P. C.; Schore, N. E., Organic Chemistry, W. H. Freeman & Company: New York, 7th Ed., 2014.
MucMurry, J.; Begley, T., The Organic Chemistry of Biological Pathways, Roberts and Company Publishers, 2005.
Brown, W.W., Organic Chemistry,Saunders College Publishing,: London 3rd Ed., 2002.
Fox, M. A.; Whitesell, J. K., Organic Chemistry,Jones and Bartlett Publishers: Sudbury, 3rd Ed., 2003..
Carey, F.A., Organic Chemistry, Mac Graw-Hill, New York, 6th Ed., 2006.

Clayden,J.; Greeves,N.; Stuart,W.,Wothers,P., Organic Chemistry, Oxford University Press, 2001.
Practical laboratory classes:
Hammond, C. N., Mohring, J. R., Morrill, T. C., Neckers, D. C., Experimental Organic Chemistry, New YorK, W. H. Freeman and Company, 1999.
Ault,A.,Techniques and Experiments for Organic Chemistry, University Science Books: USA, 6th Ed., 1998.