Therapeutic Chemistry

Recommended Prerequisites

Knowledge acquired in the courses of physical –chemical Sciences, Pharmacy Biomedical Degree.

Teaching Methods

Theoretical classes. Lectures with presentation and discussion of relevant examples.
In the theoretical-pratical classes, case studies will be presented and discussed.

Learning Outcomes

This curricular unity aims the chemical study, involving several aspects of Pharmaceutical and Biomedical Sciences related to the discovery, design and development of new drugs, the interpretation of their mechanism of action at molecular level and the elaboration of structure activity relationship -SAR.
Specific Competencies and Goals:
Give an introduction to design and strategies necessaries to new drugs discovery.
Obtain concepts in the field of Therapeutic Chemistry.
Transmit to the student the capacity to integrate one research team of drug discovery and development.

Work Placement(s)

No

Syllabus

Theoretical Lessons
General Aspects of Therapeutic Chemistry
Therapeutic Chemistry.Defenitions and Goals.
Drugs Molecular Targets.
Strategies to Discover Lead CompoundsStrategies in the investigation of new lead compounds.
“High-throughput screening” in Drug Discovery
Fragment based drug discovery
Lead-likeness and drug-likeness
Exploration of primary SAR.
Strategies for the exploration of primary SAR.
Homo and heterodimeric ligands.

Theoritical & Pratical Lessons
General topics
General Introduction to Drugs
Drug Discovery
Drug Development
Molecular Basis of Drugs
Molecular Geometry
Molecular Proprieties
Stereochemistry
Design of Analogs and Molecular Imitation
Bioisterism
Case studies
Oral presentation of the students scientific Works.

Head Lecturer(s)

Vânia Maria Antunes Moreira Bimbo

Assessment Methods

Assessment
Presentation of scientific articles: 25.0%
Exam: 75.0%

Bibliography

-Wermuth, C., The Practice of Medicinal Chemistry, Elsevier, 3rd Ed., 2008
-Thomas Gareth, Medicinal Chemistry, Wiley, 2nd Ed., 2007.