Clinical Pharmacokinetics

Recommended Prerequisites

The student should have been approved in Farmacologia and Biomatemática.
Read in english and spanish.

Teaching Methods

Lessons will be based on oral presentations of the matter following its framework in the curricular unit, being integrated with other teaching methodologies to ensure the motivation and interest of the student. Practical exercises that apply theoretical concepts, with analysis, interpretation and discussion of results will be conducted in practical classes.

Learning Outcomes

This curricular unit aims at understanding in detail each phase of drugs pharmacokinetics as well as their influence on the optimization and individualization of drug therapy.
The student should be able to characterize qualitatively and quantitatively the processes of absorption, distribution, metabolism and excretion and apply it in drug discovery programs and therapeutic drug monitoring.
The acquisition of that knowledge integrated with student ability of using mathematical models that characterize the time course of drug concentrations in biological fluids will be crucial for students to understand the influence of pathophysiological variables on drug pharmacokinetic profile and clinical application.

Work Placement(s)

No

Syllabus

Understand the general goals and study objects of pharmacokinetics and their clinical applications during drug discovery and development programs and drug therapy optimization;
Deepening the knowledge of each pharmacokinetic phase and conditioning factors involved in each one;
Understand the importance of the application of pharmacokinetics during discovery and development of new drugs;
Know and distinguish the most important mathematical models that characterize the temporal evolution of the drug concentrations in biological fluids; Calculate and interpret kinetic parameters;
Characterize and distinguish non-compartmental and compartmental pharmacokinetics models.
Apply pharmacokinetic models during the evaluation of BA/BE clinical trials and in Clinical Pharmacokinetics departments;
Understand the influence of drug properties, pathophysiological and clinical characteristics of the patient;Particular examples of drugs that are subject to pharmacokinetic monitoring in hospital.

Head Lecturer(s)

Ana Cristina Bairrada Fortuna

Assessment Methods

Assessment
Other: 10.0%
Mini Tests: 20.0%
Exam: 70.0%

Bibliography

W. Evans, J. Schentag, W. Jusko (1992); Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring. 3th Ed. Vancouver: Applied Therapeutics.
P.P. LeBlanc, et al (1999); Tratado de Biofarmácia e Farmacocinética. Nº 7, Colecção Ciência e Técnica, Instituto Piaget.
M. Rowland and T.N. Tozer (1995); Clinical Pharmacokinetics: Concepts and Applications. 3rd Ed., Lippincott Williams & Wilkins.
L. Shargel, et al (2005); Applied Biopharmaceutics & Pharmacokinetics. 5th Ed., McGraw-Hill.
S. Guimarães et al (2006); Terapêutica medicamentosa e suas bases farmacológicas. 5ª edição, Porto Ed.
M.E. Winter (2010); Basic Clinical Pharmacokinetics. 5th Ed, Williams & Wilkins.
S.S. Jambhekar & Breen P.J. (2012); Basic Pharmacokinetics. 2nd Ed., Pharmaceutical Press .
Bibliografia complementar fornecida pelo Professor da unidade curricular (Capítulo de Livros, Guidelines Internacionais e Artigos científicos).