Clinical Pharmacokinetics

Recommended Prerequisites

It is recommended that the student has knowledge of the concepts taught in the Pharmacology and Biomathematics curricular units. Additionally, it is desirable to know English and Spanish, as some supporting material can be provided in these languages.

Teaching Methods

Theoretical classes will consist of oral exposition of the subjects, with integrated pedagogical methodologies (collaborative learning and flipped learning) that encourage the student's active participation in the learning process and motivate them.

Theoretical-practical classes will be based on the case-based learning (CBL) methodology, consisting on the discussion of clinical cases that apply theoretical concepts and simultaneously simulate the reality of clinical practice, with analysis, interpretation and discussion of results.

Learning Outcomes

• Identify the objectives and object of study of Clinical Pharmacokinetics

• Knowing sources of inter- and intra-individual variability that condition the efficacy and safety of drugs

• Name the reasons underlying the use of Clinical Pharmacokinetics in Dosage Individualization

• Identify drugs and special populations that should be subject to pharmacokinetic monitoring

• Interpret graphs of the temporal evolution of plasmatic concentrations

• Apply the equations of non-compartmental, mono and bicompartmental models after single/multiple IV or extravascular administration

• Interpret the physiological value of pharmacokinetic parameters

• Apply pharmacokinetic parameters in dosage individualization/optimization

• Apply different techniques and computer programs for monitoring and dosing individualization

• Explain the procedure and need for pharmacokinetic monitoring of drugs at hospital level (antibiotics, antiepileptics, immunosuppressants, antidepressants, antipsychotics)

Work Placement(s)

No

Syllabus

• General concepts of pharmacokinetics, pharmacodynamics, biopharmaceutical phase, excretion, disposition, elimination and therapeutic range;

• Identification of the objectives and objects of study of Clinical Pharmacokinetics and relationship with concentration monitoring and individualization/optimization of pharmacological therapy;

• Characteristics of drugs and subpopulations subject to pharmacokinetic monitoring;

• Organization of a clinical pharmacokinetics service;

• Identify and predict the impact of inter- and intra-individual variability factors on the AMDE of drugs;

• Practical application of pharmacokinetic models in BD/BE assessment;

• Pharmacokinetic models;

• Use of monocompartmental models to calculate/interpretate pharmacokinetic parameters after IV/extravascular administration;

• Dosage individualization methods;

• Pharmacokinetic monitoring of antibiotics, antiepileptics, immunosuppressants, antidepressants, antipsychotics and their relationship with the disease.

Head Lecturer(s)

Ana Cristina Bairrada Fortuna

Assessment Methods

Assessment
Synthesis work: 20.0%
Frequency: 80.0%

Bibliography

BAUER L. Applied Clinical Pharmacokinetics 3rd Ed. McGraw-Hill. 2014

BAUER L. Clinical Pharmacokinetics Handbook. McGraw-Hill. 2005

BURTON E, SHAW LM, SCHENTAG JJ, EVANS WE. Applied Pharmacokinetics & Pharmacodynamics. Principles of Therapeutics  Drug  Monitoring.  4ªEd, Philadelphia, Lippincott Williams & Wilkins 2006.

DIPIRO JT. Concepts in Clinical Pharmacokinetics. Fifth Ed. American Society for Health System Pharmacists. 2010.

EVANS, W. & SCHENTAG, W.J. (1992); Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring. 3th Ed. Vancouver: Applied Therapeutics.

WINTER M.E. Basic Clinical Pharmacokinetics. 5th Ed, Williams & Wilkins 2010.

R. Silva, …, A. Fortuna, doi: 10.3390/pharmaceutics12100943

R. Silva, …, A. Fortuna, DOI: 10.3390/biomedicines10092127

R. Silva, …, A. Fortuna, DOI: 10.3390/pharmaceutics15061704

M. Aquino, …, A. Fortuna, DOI: 10.3390/antibiotics12020373

Bibliografia complementar fornecida pela Professora