Drug Design and Synthesis

Recommended Prerequisites

Frequency and approval in the discipline of Biomolecular Organic Chemistry and Therapeutic Chemistry.

Knowledge of organic chemistry, biology and biochemistry. Some knowledge of English.

Teaching Methods

Theoretical classes will be taught by showing slides, which will then be uploaded to the nónio platform.

Theoretical-practical classes will be taught by showing slides and with the active participation of students in solving problems. With regard to retrosynthesis, the exercises are done and explained by the teacher on the board, so that the whole process can be followed up in more detail.

Learning Outcomes

- Define the concept of a drug and study the various types of molecular targets.

- Analyze the different bonds involved in the interaction of drugs with their molecular targets.

- Identify the pharmacophore and define the auxophore and toxicophore

- Know the main strategies of drug design.

- Interpret the principles of design analog.

- Know how to predict the most suitable chemical modifications for interactions with molecular targets.

- Define the basic principles associated with drug synthesis.

- Retrosynthesis. Correctly apply the principles and key points governing the disconnection approach.

- Be able, based on the disconnection carried out, to design the inverse synthesis through the appropriate application of the transformation of functional groups.

- Study the main techniques for controlling preparation reactions and the structural elucidation of drugs.

- Know the basics of the different spectroscopic methods and use them to elucidate organic compounds.

Work Placement(s)

No

Syllabus

Theoretical Teaching:

- The drug and its interaction with molecular targets

- Molecular targets of drugs

- Complementarity between molecular target and drug

- Basic principles associated with drug synthesis

- Strategies for rational drug design

- Pharmacophore- and receptor-based drug design

- Principles of analog design

- Concepts of isosterism and bioisosterism, "Scaffold Hoping" and vinylogy

- Drug synthesis: Different issues involved in drug synthesis.

- The retrosynthetic approach as a planning strategy to reach the target molecule.

- Synthesis and interconversions of organic compounds.

- Case studies

- Spectroscopic techniques for controlling reactions and elucidating the structure of the products formed

Theoretical-Practical Teaching:

Solving exercises on the topics studied in theoretical teaching.

Head Lecturer(s)

Saúl Campos Pereira Costa

Assessment Methods

Assessment
Exam: 100.0%

Bibliography

• Erland Stevens, MEDICINAL CHEMISTRY - The Modern Drug Discovery Process. Copyright © 2014 by Pearson Education, Inc.

• Graham L. Patrick, An Introduction to DRUG SYNTHESIS, Jan 2015. OXFORD University Press.

• The Practice of Medicinal Chemistry (4ª Ed.), 2015. Editors: Camille Wermuth, David Aldous, Pierre Raboisson, Didier Rognan.

• Andrew Rosen, Organic Chemistry: Reactions and Overview. Editor: Raghav Malik, 2013.

• THE ART OF DRUG SYNTHESIS, Edited by Douglas S. Johnson and Jie Jack Li. Pfizer Global Research and Development. Copyright © 2007 by John Wiley & Sons, Inc.

• ORGANIC CHEMISTRY, Francis A. Carey, Robert M. Giuliano, McGraw-Hill; 8th edition (2010).