Bio-organic Chemistry

Recommended Prerequisites

Skills on subjects of the correlated curricular unities of Physical–Chemical and Biological Sciences of the Bioanalytical Sciences Degree of the Bioanalytical Sciences Course.
Knowledge of English Language.

Teaching Methods

Theoretical
Lectures with presentation and discussion of relevant examples. The slides presented are available to students.
The fundamental concepts are illustrated with examples and recent scientific discoveries.
Laboratorial
Students (groups of 2-3) perform experiments where they use the laboratory techniques acquired before, applied to the reactions and extractions of the biomolecules. In these classes, students will also be able to make oral presentations of the experimental works they will perform. Also, in these classes, students make the structural elucidation of biomolecules.

Learning Outcomes

Following Organic Chemistry (LCB) taught in the 1st academic year, this curricular unit intends to focus on some mechanisms of organic reactions and make a more detailed study of certain vital biomolecules, such as amino acids, peptides, proteins, carbohydrates and lipids, either by its biological interest, or its presence in certain harmful phenomena.

Work Placement(s)

No

Syllabus

Theoretical
General aspects of reaction mechanisms relating to the following groups of organic compounds:
-alkenes
-alkynes
-aldehydes and ketones
-carboxylic acids and derivatives: alcanoyl halides, esters and amides
-amines
Biomolecules
-Amino acids, peptides and proteins: classification and structure; peptide bond; synthesis of amino acids and
peptides
-Nucleic acids: classification and structure; DNA synthesis
-Carbohydrates: classification; stereoisomerism and structure; monosaccharide synthesis
-Lipids: classification, structure and synthesis of fatty acids
Laboratorial
Structural elucidation techniques (IR and 1H and 13-C NMR).
Execution of chemical synthesis and extraction of biomolecules.

Head Lecturer(s)

Elisiário José Tavares Silva

Assessment Methods

Assessment
Laboratory work or Field work: 30.0%
Exam: 70.0%

Bibliography

— FOX M.A., WHITESELL J.K., Organic Chemistry, 3rd Ed. Clondon, Jones and Bartlett Publ., 2004.
— SCHMUCK C., WENNEMERS H., Highlights in Bioorganic Chemistry: Methods and Applications. Wiley, 2004
—VOLHARDT, K. P. C.; SCHORE, N. E. Organic Chemistry, Structure and Function, W. H. Freeman and
Company: New YorK, 2015, 7th Ed.
— MOHRIG, J. R.; HAMMOD, C. M.; MORRIL, T. C.; NECKERS, D. C. Experimental Organic Chemistry,
Macroscale and Microscale, W. H. Freeman and Company: New York 1998
— MORRISON, R. T. e BOYD, R. N., Química Orgânica, Fundação Calouste Gulbenkian, 13ª Ed., 1996
—DUGAAS H., Biorganic Chemistry, 3rd Ed., Springer, New York. 1996.