Course Unit / Biodisposition of Xenobiotics

Biodisposition of Xenobiotics

Year
3
Academic year
2019-2020
Code
01551762
Subject Area
HEALTH SCIENCES AND TECHNOLOGIES
Language of Instruction
Portuguese
Mode of Delivery
Face-to-face
Duration
SEMESTRIAL
ECTS Credits
4.0
Type
Compulsory
Level
1st Cycle Studies

Recommended Prerequisites

Cellular and Molecular Biology, Human Physiology Cellular and Molecular Biology, Human Physiology.

Teaching Methods

The teaching methods in this curricular unit include:

  • lectures
  • problem solving-based theoretical-practical classes; search, analysis, presentation and discussion of scientific articles
  • seminarsby specialists on selected themes related to the syllabus.

Learning Outcomes

Upon completion of this curricular unit the student will be able to:

  1. Define the concept of xenobiotic, including the notions of drug and toxic
  2. Describe the main processes involved in the biodisposition of xenobiotics and the factors that affect those processes
  3. Describe the general mechanisms of action of xenobiotics
  4. Identify the main factors that determine the variability in the responses to xenobiotics and their pharmacotherapeutic implications
  5. Understand and predict the influence of biodisposition on the actions of xenobiotics.

Work Placement(s)

No

Syllabus

  1. Introduction and basic concepts; biodisposition, bioavailability and bioequivalence
  2. Cycle of xenobiotics in the organism; influence of the phsysico-chemical characteristics of the xenobiotic and of factors related to the organism on its biodisposition
  3. General pharmacokinetic principles; calculation and applications of major pharmacokinetic parameters
  4. General mechanisms of action of xenobiotics; influence of biodisposition on the actions of xenobiotics
  5. Variability in the response to xenobiotics, factors involved and pharmacotherapeutic implications; concept and applications of pharmacogenetics and pharmacogenomics.

Head Lecturer(s)

Alexandrina Maria Ferreira Santos Pinto Mendes

Assessment Methods

Assessment
Report of a seminar or field trip: 5.0%
Resolution Problems: 10.0%
Other: Presentation and discussion of scientific articles: 15.0%
Exam: 70.0%

Bibliography

- Brunton LL, Lazo JS, Parker KL (eds.) Goodman & Gilman’s The Pharmacological Basis of Therapeutics. McGraw-Hill, 11th Edition, 2006. ISBN 0-07-142280-3

- Rang, Dale, Ritter & Flower. Rang & Dale's, Pharmacology. Churchill Livingstone, Elsevier, 6th Edition, 2007. ISBN: 978-0-443-06911-6

- Artigos científicos (a indicar anualmente)/Scientific articles (to be indicated annually)