Biosensors and Biomedical Signals

Recommended Prerequisites

General Chemistry; Physics I and II, Analytical Chemistry; Organic Chemistry.

Teaching Methods

Oral presentation of theoretical concepts in powerpoint. Classes for implementing and/or exemplification of techniques and analyzes, tutorials, and even occasional guest speakers. Laboratory classes for running assemblies of biomedical instrumentation.

Monitoring the literature research work to explore a topic as exhaustive and thoroughly as possible, leading to a written report and an oral presentation. Promote critical and collaborative participation of students in a process of active learning, based on case studies, in business information, or studies still at the research stage.

Learning Outcomes

In this course students get insight about the need to develop equipment for detection, analysis and diagnosis, for specific compounds identification, in important and diversified areas of application, such as health, environment, food industry and pharmaceutical industry. They realize the interdisciplinary of several knowledge to achieve that goal mainly chemistry, physics, electronics and different branches of engineering. They get skills in the understanding and proposal of alternatives, methodologies and strategies to conciliate the bio recognition with the translation of signals, for application to new detection equipment and optimization of the existing ones.  Students get knowledge about the main transducers, used for physiological and environmental applications, contacting directly some of them in laboratory. Students also get knowledge on methods of detection, measurement and registration of biomedical signals. They know the main biomedical applications already in practice.

Work Placement(s)

No

Syllabus

1 - Biosensors

Definition of biosensor.

Components of the biosensor.

Enzymatic biosensors and immunosensors.

Transducers: electrochemical and others

Immobilization of biological compounds: chemical bonding and physical connection.

Project of biosensors.

Membrane sensor coating.

Stability of biosensors.

Applications of biosensors in the environment, medicine, food and pharmaceutical industry.

 

2 - Transducers - physiological and environmental

Static and dynamic parameters of the transducers (force, displacement, pressure, and flow velocity, acceleration, temperature, radiation, etc.). Study and application of some sensors (thermocouples, thermistors, photodiodes, gauges, etc.)

Electrical circuitry associated with the reading signal amplification and conditioning the sensor output. Amplifiers.

 

3 - Signs biomedical

Biomedical signal characteristics.

Electrocardiography. Respiratory monitoring.

Interference and noise. Passive and active analog filters.

Scan.

Assessment Methods

Assessment
Laboratory work or Field work: 10.0%
Synthesis work: 40.0%
Exam: 50.0%

Bibliography

-“Biosensors – A Practical Approach”, Ed. by A.E.G. Cass, IRL Press, Oxford University Press, 1990 

- “Sensors in Bioprocess Control”, Ed. by John V. Twork & Alexander M. Yacynych, Marcel Dekker, Inc., 1990 

- “Applied Biosensors”, Donald L. Wise, Butterworths, 1989 

- “Biosensor Principles and Applications”, Ed. by Loic J. Blum & Pierre R. Coulet, Marcel Dekker, Inc., 1991 

- “Bioanalysis and Biosensors for Bioprocess Monitoring”, vol 66 of Advances in Biochemical Engineering Biotechnology, Spring, 2000

- “Interfacial Phenomena – Equilibrium and Dynamic Effects”, 2nd ed., Clarence A. Miller e P. Neogi, CRC Press, Taylor & Francis Group, vol. 139, 2008

- Medical Instrumentation: Application and Design, 3rd Edition, John G. Webster (Editor), 1997

- The Biomedical engineering Handbook, Ed. Joseph Bronzino, CRC Press, 2000

- Sensors and Tranducers A Guide for technicians, 2nd ed. Ian Sinclair, 1998

- Biomedical Signal Processing and Signal Modeling, Eugene N. Bruce, Wiley, 2001