Chemical Synthesis

Recommended Prerequisites

Master in : Chemistry, Biochemistry, Chemical Enginiering.

Organic Chemistry, Chemical Synthesis, Organometallic Synthesis, Catalysis.

Teaching Methods

Lectures will be taught that will present topics of the syllabus. Selected topics will be presented to the students to implement the search to be able to select the most appropriate methods to perform a specific chemical transformation. The student will choose a topic related to the discipline to do an oral / written presentation. The seminars, S, intend to demonstrate the relevance of this course in professional life as synthetic chemists.

Learning Outcomes

The basic aim of this unit is learning organic synthesis methodologies ranging from taking decisions for selecting the most suitable reagents and processes, till the isolation and purification of the final products.

Thus, the student must acquire skills in advanced methods of organic synthesis to be able to  designe synthetic strategies associated with environmentally sustainable processes.

The  student must acquire the skills to successfully perform its professional lives of both, in synthetic  organic chemical synthesis and organometallic and catalysis in any research laboratory of the University or Industry.

Work Placement(s)

No

Syllabus

UC encompasses aspects of advanced chemical synthesis of organic compounds, from initial concept to final product. Particular examples of synthetic methods for the synthesis of heterocycles, macrocycles and organometallics for further development of catalysts applied in the formation of carbon-carbon bonds will be presented. Literature searches of compounds and chemical reactions to facilitate the design of experiments total syntheses, in addition to implementing isolation of the product, purification, characterization and optimization. Topics such as reaction yields versus sustainability of processes, methods of obtaining reagents, efficiency in terms of economic, environmental regulations and even problems of ethics and intellectual property protection. The UC wills also focused aspects of scale-up and reuse of solvents and catalysts so to minimize environmental impact.

Head Lecturer(s)

Maria Miguéns Pereira

Assessment Methods

Assessment
Exam: 30.0%
Synthesis work: 70.0%

Bibliography

1. “Transition Metals for Organic Synthesis: Building Blocks and Fine Chemicals”. Ed. M. Beller, C. Bolm, Wiley-VCH, Weinheim, 1998.

2. “Química Síntese e Estrutura. Uma Abordagem Prática” H.D.Burrows, Mariette M. Pereira, Escolar Editora, Lisboa 2006.

3. Inorganic Synthesis, D.F. Shriver, Wiley, Chichester, 1979.

4. Chemistry of Advanced Materials: an Overview, Ed. L.V. Interrante, M.J. Hampton-Smith, Wiley-VCH, 1997.

5. “Pharmaceutical Sunstances – Synthesis, Patents and Applications of the most relevant APIs”, A. Kleemann, J. Engel, B. Kutschen, D. Reicrent, 5th Edition, Thieme, 2009.

6. “Advanced Organic Chemistry”, F. A. Carey, R. J. Sundberg, 4th Edition, Springer, 2000.

7. "Guidebook to Organic Synthesis", R. K. Mackie, D. M. Smith, R. A. Aitken,  3rd Edition, Prentice Hall, 1999.

8. "Mecanismos de Reacções Orgânicas", Teresa M. V. D. Pinho e Melo, LIDEL-Edições Técnicas, Colecção Química – SPQ, 2005.

9. "Advanced Organic Chemistry", Jerry March, 6th Edition, Wiley, 2007.