Master’s Degree in Experimental Pathology

General Objectives of the Course

The objectives of the course are:
1.know the rules and essential legislation relating to laboratorial research in vivo with laboratory animals, in vitro and with the human species.
2.know the morphofunctional and biopathological bases of the planification and the development of experimental models in Pathology. able to express a reasoned critical opinion in terms of ethics and bioethics, including animals well-being, regarding projects of Experimental Pathology. able to plan a research project in Experimental Pathology. able to carry out laboratorial procedures with laboratory animals, namely the collection of products for analysis and take part in the post-mortem examination.
6.use tissue culture techniques for Experimental Pathology studies.

Admission Requirements

The candidates to second cycle study programs must be:
a) Holders of a first cycle or integrated cycle in the area of Health Sciences, Life Sciences and Technological Sciences;
b) Foreign degree holders of first cycle study programmes organised according to the Bolonha Process by a country where this Process is available, in the areas mentioned in point a);
c) Foreign degree holders of courses recognised with the objectives of a licensee degree by the Scientific Council of the Faculty of Medicine of the University of Coimbra;
d) Holders of academic, scientific or professional curricula recognised by the Scientific Council of the Faculty of Medicine of the University of Coimbra, declaring abilities of the candidate to prosecute this study programme.

Candidates should check the admission requirements available on this site, in addition to the information provided here.

Professional Goals

This Master’s degree is intended to create conditions for the improvement of research capacity in the medium and long term. Thus, this Master’s degree contributes to the training of new specialists even more able to practice scientific research, particularly in the area of Pathology, using experimental models in vivo and in vitro. It promotes an increase in the quality of professional and scientific activities and in research.

Mode of Study

The course is delivered in full time or part time attendance and daytime schedule.

Teaching / Evaluation language(s)


Examination Regulations, Assessment and Grading

As assessment is a pedagogical activity inseparable from the teaching process, its aim is to establish the students' competencies and knowledge, their critical sense, ability to recognize and resolve problems, as well as their written and oral presentation skills. Students may only register for exams for classes they are currently registered for under the terms of number 6 of article 4 of the University of Coimbra Pedagogical Policy. The following are examples of assessment items: Oral or written exams, written or practical work, individual and group projects that may require an oral defense, as well as class participation. Assessment for each class may include one or more of the above mentioned items. Grading is based on a scale of 0 to 20 and a grade of 10 is required to pass. Whenever assessment includes more than one item, the final grade is calculated by taking into account the relative weight of each item according to a formula published in the course outline under the terms of number 2 of article 7 of the UC Pedagogical Policy.

Learning Objectives and Intended Skills

During the present study programme we work the main knowledge to work in the laboratory with safety and to have competencies in planning and develop projects of research in Experimental Pathology, in its main areas. The
students must acquire the main objectives:
Know and apply procedures for Laboratory Safety, Laboratory Waste Management, Animal Facilities, Animal Maintenance and Manipulation.
Know and apply techniques for Light Microscopy, Histochemistry, Immunohistochemistry for Optical Microscopy, Electronic Microscopy, Molecular Biology, Morphometrics and Instrumental Techniques of Image Analysis, Tissue
cultures, Organ Baths, Informatics Simulation, Experimental techniques for Nuclear Medicine, Imagiology and Neurophysiology.
Know the basis about biomaterials and its medical applications. Know the principles of biomaterial testing, mainly concerning to biocompatibility.
Know and perform the procedures of collecting tissue fragments for Experimental Pathology and join the execution of the routine techniques of Histology; morphologic basis for the diagnosis in light microscopy.
Perform simple diagnosis of neoplastic and non-neoplastic lesions.
Recognise the differences between the morphologic lesions among different species, comparing to the human being.
Make the project and perform experimental models of neoplastic and non-neoplastic pathology of the different organic systems.
Perform an experimental model: project, accomplishment and report.
Know the organic action of toxics, its metabolization and the concepts about toxicity and reference values; techniques for toxic identification, applications and limitations; mechanisms of toxic actions specially for liver,
kidney, heart, lung and nervous system; models of toxicology in vitro and in vivo. Project and accomplish these models. Know laboratory procedures for stem cells conditioning, mainly adult stem cells.
Know and accomplish procedures for analgesia and anesthesia in the laboratory small animals in experimental surgery, suturing techniques and surgical procedures in digestive and urinary tracts and splenectomy.
Make contact with the reality in the society, mainly the clinical fields where the results of Experimental Pathology research are important and in the enterprises which resources and technologies can be applied in this kind of
The evaluation is always performed by a written exam, complemented in some cases with other exams: practical, technical/laboratory or monograph.

Course Coordinator(s)

Maria Filomena Rabaça Roque Botelho

ECTS Departmental Coordinator(s)

Maria Joana Lima Barbosa Melo

Recognition of Prior Learning

Recognition of prior learning is carried out in accordance with the Academic Regulation of the University of Coimbra.

Qualification Requirements and Regulations

The legal framework for the qualification is established by the decrees: Decree-Law no. 74/2006, 24th March, amended and republished by the decree: DL no 107/2008, 25th June; Ordinance no. 782/2009, 23rd de July.

Graduation Requirements

The Master's degree requires the successful completion of all units of study in the study plan, as well as a dissertation or the stage, totalling 120 ECTS.

Access to Further Studies

The Master’s degree in Experimental Pathology will be achieved when the student obtains 120 ECTS. The course duration is 4 semesters. After obtaining a Master's degree it is possible to advance to the third cycle of studies or PhD.

Study Programme

Master's Degree in Experimental Pathology

Academic year

Course Type
2nd Cycle Studies - Advanced Specialisation Master Programme

DGES Code: 6204

Qualification Awarded: Mestre

Duration: 2 Year(s)

ECTS Credits: 120.0

Category: Advanced specialization second cycle


Call for Applications


1st Semester
Start date: 11-09-2023
End date: 16-12-2023
2nd Semester
Start date: 05-02-2024
End date: 23-05-2024


Agência de Avaliação e Acreditação do Ensino Superior
2017-10-24 a 2023-10-23
Direcção Geral de Ensino Superior

Nº Registo: R/A-Ef 1675/2011/AL01