Department
Department of Life Sciences (DCV), Faculty of Sciences and Technology, University of Coimbra (FCTUC), Coimbra, Portugal
R&D Unit
CIEPQPF - Chemical Process Engineering and Forest Products Research Centre, FCTUC
Scientific Interests
Biomaterials: controlled drug release; modification and characterization of surfaces; hemocompatibility and biocompatibility; self-assembled monolayers.
Participation in financed research projects
"NABIA - New Approach to Bioremediation Using Algae". Ref. PTDC/BTA-GES/2740/2020 (Fundação para a Ciência e a Tecnologia - FCT). Team member. 2021-2024.
"Wearable textile patches for optical biosensing in healthcare applications". Concurso para Jovens Investigadores do Instituto de Materiais de Aveiro (CICECO – Universidade de Aveiro). Team member. 2022-2024.
"Stereostrat - Sterilization of clinically active hydrogels: looking for efficient strategies", Ref. PTDC/CTMBIO/3640/2014 (Fundação para a Ciência e a Tecnologia - FCT). Team leader. 2016-2019.
"Surflenses − Surface modifications to control drug release from therapeutic ophthalmic lenses". M-ERA.NET Transnational Call 2012. Ref. M-ERA.NET/0006/2012 (FCT). Team lider. 2014-2017.
"My first contact with Science". Call “Parents with Science”, for promoting science and technology in primary schools. Ref. PcC 170 (Ciência Viva). Team member. May-December 2013
"NanoBioCats – Novel nanostructured polymeric materials for concurrent biocatalysis and separation". Ref. PTDC/CTM-POL/112289/2009 (FCT). Team member. 2011-2014
"The role of energetic metabolism in cancer", Ref. 26/07 (CIMAGO − Centro de Investigação em Meio-Ambiente, Genética e Oncobiologia). Team member. 2007-2013
"Nanochemistry of magnetic/luminescent composites for in vitro medical diagnosis applications". Ref. PTDC/QUI/67712/2006 (FCT). Team member. 2008-2010
"Nanoengineering of magnetic-luminescent particles for cell labelling and separation". Ref. 3.64.33.7/NANOENGENHARIA/CTS15 (Instituto de Investigação da Universidade de Aveiro). Team member. 2003-2005
“Development of new polyurea/polyurethane-based membranes for blood oxygenators". Ref. POCTI/FCB/47661/2002 (FCT). Team member. 2002-2006
“Design and Evaluation of a Heparin Adsorbing Filter for Application in Haemo-Dialysis". BRITE EURAM Programme. Team member. 1992–1998
"New disposable biosensors for clinical applications". Ref. PBIC/T/PSAU/1532/92 (Junta Nacional de Investigação Científica e Tecnológica - JNICT). Team member. 1992–1996
"Characterization of the crosslinking induced in polysaccharides grafted with synthetic polymers, using different crosslinking agents". Individual grant (INIDA). 1991–1992
"Preparation, characterization and study of immobilized biocatalysts onto polymeric supports" − Ref. 87182/BIO (JNICT). Team member. 1989–1991
Publications
Periodicals
L. M. Vaz, R. Branco, P. V. Morais, A. J. Guiomar," Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings", Membranes, 13, 877 (2023)
A. J. Guiomar, A. M. Urbano, "Polyhexanide-releasing membranes for antimicrobial wound dressings: a critical review", Membranes, 12, 1281 (2022)
P. Sahariah, A. P. Vieira, A. J. Guiomar, P. Alves, M. Másson, "Utilization of TBDMS chitosan for synthesis of photoactive chitosan derivatives and application in photografting on ophthalmic lens material", React. Funct. Polym., 153, 104600 (2020)
H. P. Filipe, D. Bozukova, A. Pimenta, A. P. Vieira, A. S. Oliveira, R. Galante, A.Topete, M. Masson, P. Alves, P. Coimbra, M. H. Gil, A. J. Guiomar, J. Mata, R. Colaço, B. Saramago, L. Werner, N. Mamalis, A. P. Serro, “Moxifloxacin-loaded acrylic intraocular lenses: in vitro and in vivo performance”, J. Cataract Refract. Surg., 45, 1808-1817 (2019)
A. Pimenta, A. P. Vieira, P. Alves, P. Coimbra, M. H. Gil, D. Bozukova, J. L. G. Mata, A. J. Guiomar, R. Colaco, B. Saramago, and A. P. Serro, “Surface grafting with monomers to control drug release from intraocular lenses”, Ann. Med., 50, S58-S59 (2018)
A. P. Vieira, A. F. R. Pimenta, D. Silva, M. H. Gil, P. Alves, P. Coimbra, J. L. G. C. Mata, D. Bozukova, T. R. Correia, I. J. Correia, A. P. Serro, A. J. Guiomar, “Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin”, Eur. J. Pharm. Biopharm., 120, 52-62 (2017)
A. F. R. Pimenta, A. P. Vieira, R. Colaço, B. Saramago, M. H. Gil, P. Coimbra, P. Alves, D. Bozukova, T. R. Correia, I. J. Correia, A. J. Guiomar, A. P. Serro, “Controlled release of moxifloxacin from intraocular lenses modified by Ar plasma-assisted grafting with AMPS or SBMA: an in vitro study”, Colloids Surf. B, Biointerfaces, 156, 95-103 (2017)
H. P. Filipe, D. Bozukova, A. Pimenta, A. P. Vieira, P. Alves, P. Coimbra, A. J. Guiomar, M. H. Gil, J. L. G. Mata, A. P. Serro, “Surface modification of intraocular lenses towards controlled drug delivery”, Acta Ophthalmol., 93, S255, ABS15-0561 (2015)
Teresa R. Silva, Daniela P. Rodrigues, Jorge M. S. Rocha, M. Helena Gil, Susana C. S. Pinto, José A. Lopes-da-Silva, A. J. Guiomar, “Immobilization of trypsin onto poly(ethylene erephthalate)/poly(lactic acid) nonwoven nanofiber mats”, Biochem. Eng. J., 104, 48-56 (2015)
P. C. Pinheiro, C. T. Sousa, J. P. Araújo, A. J. Guiomar, T. Trindade, “Functionalization of nickel nanowires with a fluorophore aiming at new probes for multimodal bioanalysis”, J. Colloid Interface Sci., 410, 21-26 (2013)
M. J. Gonçalves, A. C. C. Santos, P. Coelho P, A. N. Costa, C. F. D. Rodrigues, A. J. Guiomar, M. S. Santos, M. C. Alpoim e A. M. Urbano, “Changes in Glucose Uptake Rate and in the Energy Status of PC-12 Cells Acutely Exposed to Hexavalent Chromium, an Established Human Carcinogen”, Toxicol. Environ. Chem., 93, 1202-1211 (2011)
M. J. Gonçalves, A. C. C. Santos, P. Coelho P, A. N. Costa, C. F. D. Rodrigues, M. S. Santos, A. J. Guiomar, M. C. Alpoim, A. M. Urbano, “Changes in the energy status and glucose uptake rate of PC-12 cells induced by acute subcytotoxic or mildly cytotoxic hexavalent chromium insults”, FEBS J., 277, 70-70 (2010) [Abstract from the “35th Congress of the Federation of European Biochemical Societies, June 26-July 01, 2010, Gothenburg, Sweden.]
M. C. F. Besteiro, A. J. Guiomar, C. A. Gonçalves, V. A. Bairos, M. N. de Pinho, M. H. Gil, "Characterization and in vitro hemocompatibility of bi-soft segment, polycaprolactone-based poly(ester urethane urea) membranes", J. Biomed. Mater. Res., 93A, 954-964 (2010)
A. L. Daniel-da-Silva, S. Fateixa, A. J. Guiomar, B. F. O. Costa, N. J. O. Silva, T. Trindade, B. J. Goodfellow e A. M. Gil, "Biofunctionalized magnetic hydrogel nanospheres of magnetite and k-carrageenan", Nanotechnology, 20, 355602 (2009)
M. A. Martins, M. C. Neves, A. C. C. Esteves, P. I. Girginova, A. J. Guiomar, V. S. Amaral, T. Trindade, “Biofunctionalized ferromagnetic CoPt3/polymer nanocomposites”, Nanotechnology, 18, 215609 (2007)
D. P. Queiroz, I. M. Pinto, M. C. F. Besteiro, A. F. M. Silva, M. H. Gil, A. J. Guiomar, M. N. de Pinho, "Surface and Hemocompatibility Studies of Bi-soft Segment Polyurethane Membranes", Int. J. Artif. Organs, 29, 866-872 (2006)
M. I. Pinto, D. P. Queiroz, M. H. Gil, A. J. Guiomar, M. N. Pinho, “Polyurethane-polyurea membranes for blood oxygenation“, Mater. Sci. Forum III, 514-516, 863–867 (2006)
A. J. Guiomar, S. D. Evans, J. T. Guthrie, “Evaluation of the Permeability of Modified Cellulose Acetate Propionate Membranes for Use in Biosensors Based on Hydrogen Peroxide Detection”, Cellulose, 8, 297–301 (2001)
A. J. Guiomar, J. T. Guthrie, S. D. Evans, “Use of Mixed Self-Assembled Monolayers in a Study of the Effect of the Micro-Environment on Immobilized Glucose Oxidase”, Langmuir, 15, 1198–1207 (1999)
A. J. Guiomar, S. D. Evans, J. T. Guthrie, “Immobilisation of Glucose Oxidase onto a Langmuir-Blodgett Film of a Cellulose Derivative Deposited on a Self-Assembled Monolayer” Supramol. Sci., 4, 279–291 (1997)
A. J. Guiomar, J. T. Guthrie, “Immobilisation of Glucose Oxidase in Cellulosic Membranes Attached to Ordered Assemblies”, Abstr. Pap. Am. Chem. Soc., 213, 100 CELL (1997)
A. Alcantara, M. H. Gil, A. J. Guiomar, M. Belmonte, M. C. Sobral, C. Torres, J. V. Sinisterra, “Organic Reactions Catalysed by Insolubilised Enzymes. Part III. Synthesis of Peptides Catalyzed by Alpha-Chymotrypsin Immobilised on Graft Copolymers”, J. Mol. Catal., 101, 255–265 (1995)
M. Alves da Silva, M. H. Gil, A. J. Guiomar, C. Martins, J. T. Guthrie, “Immobilisation of Alpha-Chymotrypsin onto Hydrolised Polyethylene-g.co-HEMA”, J. Appl. Polym. Sci., 41, 1629–1639 (1990); erratum: J. Appl. Polym. Sci., 43, 219 (1991)
M. Alves da Silva, M. H. Gil, J. Guiomar, E. Lapa, E. Machado, M. Moreira, J.T. Guthrie, S. Kotov, “The Immobilisation of Enzymes onto Polyethylene-g.co-methacrylic acid, Polyethylene-g.co-HEMA-co-methacrylic acid and Polyethylene-g.co-methacrylic acid-co-HEMA”, Radiat. Phys. Chem., Int. J. Radiat. Appl. Instrum., Part C, 36, 589–593 (1990)
M. Alves da Silva, C. G. Beddows, M. H. Gil, J. T. Guthrie, A. J. Guiomar, A. P. Piedade, “The Application of Radiation Induced Processed Copolymers for Biocatalysts Immobilisation”, Radiat. Phys. Chem., Int. J. Radiat. Appl. Instrum., Part C, 35, 98–101 (1990)
Book Chapters
K. Gudnason, S. Sigurdsson, F. Jonsdottir, A. J. Guiomar, A. P. Vieira, P. Alves, P. Coimbra, and M. H. Gil, “Modelling the release of moxifloxacin from plasma grafted intraocular lenses with rotational symmetric numerical framework”, In: I. Rojas, F. Ortuño (eds.), Bioinformatics and Biomedical Engineering. IWBBIO 2018. Lecture Notes in Computer Science, vol. 10813, pp. 329-339, Springer, Cham, Switzerland (2018)
M. Black, A. J. Guiomar, J. T. Guthrie, R. A. Morris, “Immobilisation of Cholesterol Oxidase on a Hydroxypropyl Cellulose-g.co-Acrylic Acid Support System: Relevance to Biosensor Development” in “Cellulosics: Materials for Selective Separations and Other Technologies” (J. F. Kennedy, G. O. Phillips, eds.), pg.171–181, Ellis Horwood, New York, USA (1993)
Digital Encyclopedia Entry
A. J. Guiomar, A. M. Urbano, "Commercial Antimicrobial Wound Dressings Based on Polyhexanide-Releasing Membranes". In Encyclopedia - Scholarly Community Encyclopedia, 39592, MDPI, Basel, Switzerland (2022)
Thesis and Monographs
A. J. Guiomar, “The Influence of the Micro-Environment on the Structure and Activity of Immobilised Glucose Oxidase”, PhD Thesis, University of Leeds (1997)
A. J. Guiomar, “Conformational analysis of proteins“, Monograph, University of Coimbra (1990)
A. J. Guiomar, “Immobilised Cholesterol Oxidase in Amperometric Biosensors", MSc Thesis, University of Leeds (1989)
A. J. Guiomar, “Immobilization of alpha-Chymotrypsin and Cellulase onto Polymeric Supports", BSc Thesis, University of Coimbra (1988)
Lectured course units
Biocompatibility of Biomaterials - MSc in Biochemistry, FCTUC (lecturer)
Biomaterials - MSc in Biochemistry, FCTUC (lecturer)
Introduction to the Biochemistry Laboratory – BSc in Biochemistry, FCTUC (co-lecturer)
Biochemistry Laboratories I - BSc in Biochemistry, FCTUC (co-lecturer)
Biomaterials - BSc in Biochemistry, FCTUC (lecturer)
Enzymology and Biocatalysis - MSc in Biochemical Engineering, FCTUC (co-lecturer)
Biomaterials - MSc in Biochemical Engineering, FCTUC (co-lecturer)
Macromolecules I / Polymer Chemistry I - BSc in Chemistry, FCTUC (co-lecturer)